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June 20, Friday
Arrival and registration
19.30 Invitation
Opening lecture - update of CA research
(C. T. Supuran, S. Parkkila)
20.30 Welcome dinner
June 21, Saturday
Breakfast (7.30 -9.00)
Session 1 (9,00 -12,30): Structure, kinetics and catalytic mechanisms of CA9.00 - 9.30 |
Chemical rescue of proton transfer in site-specific mutants of carbonic anhydrase II: Binding sites and the source of H/D isotope effects. |
C. K. Tu |
9.30 -10.00 |
Iron Replaces Zinc in the g Class of Carbonic Anhydrase |
J. G. Ferry |
10.00 -10.30 |
The evolution of an efficient carbonic anhydrase: implication for the mechanism based on structure-function studies on active site mutants |
B.-H. Jonsson |
10.30 -11.00 |
Coffee break |
|
11.00 -11.30 |
Structure and function of membrane-associated carbonic anhydrases |
D. W. Christianson |
11.30 -12.00 |
Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1 and its sulfanilamide adducts |
F. Briganti |
12.00 -12.30 |
Structural and kinetic analysis of proton transfer sites in human carbonic anhydrase II |
R. McKenna |
Lunch (12.30-13.30)
Session 2 (14,00-18,30): Targeted modification of CA activity for therapeutic purposes
| 14.00 -14.30 | Structure-based drug design of Carbonic Anhydrase Inhibitors | G. Klebe |
| 14.30 -15.00 | Lessons learned and lessons to learn: News from known fellows | J. Antel |
| 15.00 -15.30 | Development of CA inhibitors for ophthalmological use | A. Casini |
| 15.30 -16.00 | 3D QSAR studies for affinity and selectivity prediction of carbonic anhydrase inhibitors | A. Weber |
| 16.00 -16.30 | Coffee break | |
| 16.30 -17.00 | Carbonic anhydrase inhibitors in epilepsy | B. Masereel |
| 17.30 -18.00 | Carbonic anhydrase activators | A. Scozzafava |
| 18.00 -18.30 | Carbonic anhydrase in cognition and mood regulation | M.-K. Sun |
| 18.30 -19.00 | E7070 (indisulam), a sulfonamide anticancer agent in clinical development | T. Owa |
Dinner (19.00-20.00)
June 22, Sunday
Breakfast (7.30 -9.00)
Session 3 (9,00-13,00):
CA expression in diseases and pathological roles - molecular aspects
Chairmen: N. Carter, J.
Pastorek
9.00 -9.30 |
Low-dose acetazolamide reduces the acute hypoxic response in men and abolishes O2-CO2 interaction |
L. J. Teppema |
| 9.30 -10.00 | Carbonic anhydrase and tumour hypoxia |
P. H. Maxwell |
10.00 -10.30 |
Soluble form of carbonic anhydrase IX ( CAIX) in the serum and urine of renal carcionoma patients | J. Zavada |
10.30 -11.00 |
Consequences of genetically manipulated expression of CA IX |
S. Pastorekova |
| 11.00 -11.30 | Coffee break | |
11.30 -12.00 |
Carbonic anhydrase in skin tumors |
A. Mastrolorenzo |
12.00-12.30 |
I.Nishimori | |
12.30 -13.00 |
Functional genomics of the mitochondrial carbonic anhydrases | W.S. Sly |
Lunch (13.30-14.30)
Evening program (19.00 -23.00):
Performance of Children’s Folk Dancing Group with life music, barbecue.
June 23, Monday
Morning program (9.30-11.00)
Trip to Modra (excursion to ceramics manufacture)
Lunch (12.30-13.30)
Session 4 (14,00-18,00): CA
expression in normal tissues and functional implications
| 14.00 -14.30 | The bicarbonate transport metabolon | J.Casey |
| 14.30-15.00 | Permeation of CO2 across the red cell membrane | G. Gros |
| 15.00 -15.30 | Novel membrane-associated CA isozymes in mouse and rat kidney: localization and regulation | K. Kaunisto |
| 15.30 -16.00 | Carbonic anhydrase expression in rabbit kidney: New isoforms, new functions | G. J. Schwartz |
| 16.00 -16.30 | Coffe break | |
| 16.30 -17.00 | The role of muscle carbonic anhydrase in metabolism and fatigue | P. Wetzel |
| 17.00-17.30 | Secretion of CA VI to mammalian milk and its possible novel functions in the gastrointestinal tract | H. Rajaniemi |
| 17.30-18.00 | Effect of CA inhibition on vascular smooth muscle intracellular calcium, pH and membrane channels | E. R. Swenson |
Wine tasting and dinner (19.00-21.00)
June 24, Tuesday
Breakfast (7.30 -9.00)
Session 5
(9,00-12,00): CAs in animals, plants and bacteria, their impact on health and ecology
Chairman: D.Hewett/Emmett
9.00 - 9.30 |
Evolutionary origins of the eukaryotic a -carbonic anhydrases and diversity of the enzymatically-inactive carbonic anydrase isoform genes |
R. E. Tashian |
9.30 -10.00 |
Carbonic anhydrase(s) of the larval mosquito: molecular biology, expression profile and crucial role in the physiology of the alkaline gut |
P. J. Linser |
10.00 -10.30 |
Human malarial parasite carbonic anhydrase: molecular cloning, functional expression and characterization |
J. Krungkrai |
10.30 -11.00 |
Coffee Break |
|
11.00 -11.30 |
Carbonic anhydrase localisation in the avian oviduct in connection with embryonic exposure to environmental estrogens |
L. Holm |
11.30 -12.00 |
On the occurrence of carbonic anhydrase in chicken extra-embryonic membranes |
G. Gabrielli |
Lunch (12.15-13.15)
Afternoon program (13,45-18,00):
Trip to Bratislava
Evening program (19,30):
Dinner and wine tasting
June 25, Wednesday
Departure